MiR-539 inhibits cell proliferation and invasion by targeting CARMA1 in NSCLC

MicroRNAs (miRNAs) play an important role in the development and progression of non-small cell lung cancer (NSCLC). Recently, several studies have shown that miR-539 is down regulated in various cancers, however, its expression and function in NSCLC remain unclear. In this study, we found that miR-539 was downregulated in NSCLC tissues and cell lines. Overexpression of miR-539 suppressed cell proliferation and invasion in A549 cells. Furthermore, our results also shown miR-539 reduction was associated with increased CARMA1 expression levels in NSCLC tissues and luciferase activity assays showed that CARMA1 is a direct target ofmiR-539. Taken together, our study demonstrates that miR-539 plays important roles in NSCLC pathogenesis, implicating potential application in cancer therapy.